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Papers that changed AI, with a plain-language explainer for each.

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  1. 2026

    GLM-5: from Vibe Coding to Agentic Engineering

    arXiv

    Zhipu's GLM-5 report describes a 744-billion-parameter mixture-of-experts model built on sparse attention and asynchronous reinforcement learning, aimed at moving AI-assisted programming from vibe coding toward agentic engineering.

    Large language modelsChinaAgents & tool use

  2. 2026

    Terminal-Bench: Benchmarking Agents on Hard, Realistic Tasks in Command Line Interfaces

    arXiv

    Terminal-Bench 2.0 is a curated benchmark of 89 hard tasks carried out in computer terminal environments, built to measure how well AI agents handle realistic command-line work; frontier models and agents score below 65% on it.

    Research historyAgents & tool useCode

  3. 2024

    Accurate structure prediction of biomolecular interactions with AlphaFold 3

    Nature

    AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.

    Deep learningScienceBiomedicine

  4. 2024

    LiveCodeBench: Holistic and Contamination Free Evaluation of Large Language Models for Code

    arXiv

    A benchmark for code LLMs that keeps collecting fresh contest problems from LeetCode, AtCoder and CodeForces, so that scores reflect ability rather than memorised test data, and that also tests code repair and execution reasoning.

    Large language modelsResearch historyData & datasets

  5. 2023

    SWE-bench: Can Language Models Resolve Real-World GitHub Issues?

    arXiv

    A benchmark of 2,294 real software engineering problems taken from GitHub issues and the pull requests that resolved them, in which a model must edit a codebase to fix an issue; on release the best model solved under 2% of them.

    Research historyAgents & tool useData & datasets

  6. 2021

    Program Synthesis with Large Language Models (MBPP)

    arXiv

    A 2021 arXiv paper by Austin, Odena, Nye and eight other authors that introduced MBPP, a benchmark of 974 short Python programming tasks, and measured how language models from 244M to 137B parameters turn natural-language descriptions into working code.

    Large language modelsResearch historyData & datasets

  7. 2021

    Highly accurate protein structure prediction with AlphaFold

    Nature

    The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.

    Research historyScienceBiomedicine

  8. 2021

    Evaluating Large Language Models Trained on Code (Codex / HumanEval)

    arXiv

    A 2021 paper from OpenAI introduces Codex, a GPT model fine-tuned on public GitHub code, and HumanEval, an evaluation set that judges generated Python programs by whether they work rather than by how closely they match a reference.

    Large language modelsResearch historyData & datasets

  9. 2015

    U-Net: Convolutional Networks for Biomedical Image Segmentation

    arXiv

    A convolutional network for biomedical image segmentation, posted to arXiv on May 18, 2015, that trains end to end from very few annotated images and won the ISBI cell tracking challenge 2015 in its categories.

    Research historyComputer visionBiomedicine

  10. 2012

    Large Scale Distributed Deep Networks

    NeurIPS

    A 2012 NIPS paper by Jeffrey Dean, Andrew Ng and colleagues that introduced DistBelief, a framework for training deep networks across clusters of thousands of machines, together with the Downpour SGD and Sandblaster optimisation procedures.

    Deep learningHardware & computeCloud