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Papers that changed AI, with a plain-language explainer for each.
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- 2025
ARC-AGI-2: A New Challenge for Frontier AI Reasoning Systems
arXiv
A 2025 paper introducing ARC-AGI-2, a benchmark of input-output puzzle tasks built to measure abstract reasoning in frontier AI systems, with human testing as a baseline and a task set designed to give a more granular signal of progress.
- 2024
FrontierMath: A Benchmark for Evaluating Advanced Mathematical Reasoning in AI
arXiv
FrontierMath is a benchmark of hundreds of original, unpublished mathematics problems written and vetted by expert mathematicians, introduced by Epoch AI to test advanced mathematical reasoning in AI. At release, state-of-the-art models solved under 2% of the problems.[^1][^2]
- 2024
Accurate structure prediction of biomolecular interactions with AlphaFold 3
Nature
AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.
- 2023
Scaling deep learning for materials discovery
Nature
A 2023 Nature paper from researchers at Google DeepMind presenting a scaled-up deep-learning approach to predicting stable crystal structures, screening 2.2 million candidates and reporting a large jump in stability-prediction accuracy.
- 2023
GPQA: A Graduate-Level Google-Proof Q&A Benchmark
arXiv
GPQA is a benchmark of 448 expert-written multiple-choice questions in biology, physics and chemistry, built so that skilled non-experts cannot look the answers up, and hard enough that the strongest GPT-4 baseline scored 39% while domain experts reached 65%.
- 2022
Learning skillful medium-range global weather forecasting
Science
GraphCast is a graph neural network trained on four decades of reanalysis data that produces 10-day global weather forecasts at 0.25 degree resolution in under a minute, outperforming the leading operational deterministic systems on most verification targets.
- 2022
Magnetic control of tokamak plasmas through deep reinforcement learning
Nature
A 2022 Nature paper by Degrave, Felici and colleagues showing that a deep reinforcement learning controller can learn on its own to command all of a tokamak's magnetic control coils, producing and holding a range of plasma shapes.
- 2021
Highly accurate protein structure prediction with AlphaFold
Nature
The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.
- 2020
NeRF: Representing Scenes as Neural Radiance Fields for View Synthesis
arXiv
A 2020 paper by Mildenhall, Srinivasan, Tancik, Barron, Ramamoorthi and Ng that represents a scene as a neural radiance field: a network mapping 5D coordinates to density and colour, optimized from a sparse set of images with known camera poses.
- 2019
Mastering Atari, Go, chess and shogi by planning with a learned model
Nature
MuZero is a DeepMind reinforcement-learning algorithm that learns a model of its environment and plans inside that model, mastering Atari, Go, chess and shogi without being given the rules of those games.
- 2019
On the Measure of Intelligence (ARC-AGI)
arXiv
A 2019 paper by Francois Chollet that defines intelligence as skill-acquisition efficiency and introduces the Abstraction and Reasoning Corpus (ARC), a benchmark of grid tasks that assumes no specialised knowledge or language.
- 2018
Neural Ordinary Differential Equations
arXiv
A 2018 paper by Chen, Rubanova, Bettencourt and Duvenaud that replaces a fixed sequence of hidden layers with a neural network describing the derivative of the hidden state, so outputs are computed by an ODE solver — yielding continuous-depth models with constant memory cost.[^1]
- 2018
Group Normalization
arXiv
Group Normalization is a 2018 paper by Yuxin Wu and Kaiming He that proposes normalizing channels in groups, independent of batch size, to address batch normalization's weakness when batches are small.
- 2017
A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play
Science
A 2017 arXiv paper, later published in Science, reporting that a single self-play reinforcement learning algorithm, AlphaZero, mastered chess, shogi and Go and beat strong specialised programs in each.
- 2017
mixup: Beyond Empirical Risk Minimization
arXiv
mixup is a training principle from a 2017 paper by Zhang, Cisse, Dauphin and Lopez-Paz that trains networks on convex combinations of pairs of examples and their labels, improving generalisation on image, speech and tabular benchmarks.
- 2017
Mastering the game of Go without human knowledge
Nature
AlphaGo Zero learned Go only by playing against itself, starting from random play, and beat the earlier champion-defeating AlphaGo 100 games to 0 after three days of training. The Nature paper appeared in October 2017.
- 2016
Identity Mappings in Deep Residual Networks
arXiv
A 2016 analysis of residual networks arguing that with identity skip connections and the activation placed after addition, signals travel directly between blocks; a new residual unit built on this eases training, and a 1001-layer network reaches 4.62% error on CIFAR-10.
- 2015
Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift
arXiv
A 2015 paper by Sergey Ioffe and Christian Szegedy that proposed normalising each layer's inputs per training mini-batch, which allowed higher learning rates, looser initialisation and much faster training of deep networks.
- 2015
Deep learning
Nature
A 2015 Nature review by Yann LeCun, Yoshua Bengio and Geoffrey Hinton explaining deep learning: models of multiple processing layers that learn layered representations of data, and the results this produced in speech, vision and other fields.
- 2014
Adam: A Method for Stochastic Optimization
arXiv (ICLR 2015)
Adam is a stochastic optimisation algorithm from a 2014 paper by Diederik P. Kingma and Jimmy Ba that sets per-parameter step sizes from running estimates of the gradient's first and second moments, needing little memory and little hyper-parameter tuning.