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Papers that changed AI, with a plain-language explainer for each.
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- 2024
FrontierMath: A Benchmark for Evaluating Advanced Mathematical Reasoning in AI
arXiv
FrontierMath is a benchmark of hundreds of original, unpublished mathematics problems written and vetted by expert mathematicians, introduced by Epoch AI to test advanced mathematical reasoning in AI. At release, state-of-the-art models solved under 2% of the problems.[^1][^2]
- 2024
Accurate structure prediction of biomolecular interactions with AlphaFold 3
Nature
AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.
- 2023
Scaling deep learning for materials discovery
Nature
A 2023 Nature paper from researchers at Google DeepMind presenting a scaled-up deep-learning approach to predicting stable crystal structures, screening 2.2 million candidates and reporting a large jump in stability-prediction accuracy.
- 2023
GPQA: A Graduate-Level Google-Proof Q&A Benchmark
arXiv
GPQA is a benchmark of 448 expert-written multiple-choice questions in biology, physics and chemistry, built so that skilled non-experts cannot look the answers up, and hard enough that the strongest GPT-4 baseline scored 39% while domain experts reached 65%.
- 2022
Learning skillful medium-range global weather forecasting
Science
GraphCast is a graph neural network trained on four decades of reanalysis data that produces 10-day global weather forecasts at 0.25 degree resolution in under a minute, outperforming the leading operational deterministic systems on most verification targets.
- 2022
Scalable Diffusion Models with Transformers (DiT)
arXiv
A 2022 paper by William Peebles and Saining Xie that replaces the U-Net backbone of diffusion models with a transformer operating on latent patches, showing that image quality improves predictably as compute grows and reaching a state-of-the-art FID of 2.27 on ImageNet 256×256.
- 2022
Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding (Imagen)
arXiv
Imagen is a text-to-image diffusion model that uses a large pretrained language model to encode prompts; it reached a zero-shot FID of 7.27 on COCO and introduced the DrawBench benchmark.
- 2022
Magnetic control of tokamak plasmas through deep reinforcement learning
Nature
A 2022 Nature paper by Degrave, Felici and colleagues showing that a deep reinforcement learning controller can learn on its own to command all of a tokamak's magnetic control coils, producing and holding a range of plasma shapes.
- 2021
High-Resolution Image Synthesis with Latent Diffusion Models
arXiv 2112.10752 (CVPR 2022)
A 2021 paper by Rombach, Blattmann, Lorenz, Esser and Ommer that runs diffusion models inside the latent space of pretrained autoencoders, cutting the compute needed for high-resolution image synthesis while adding cross-attention for text and bounding-box control.
- 2021
Highly accurate protein structure prediction with AlphaFold
Nature
The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.
- 2021
Zero-Shot Text-to-Image Generation (DALL·E)
arXiv
A 2021 OpenAI paper describing a single 12-billion-parameter autoregressive transformer trained on 250 million image-text pairs, which generates images from text and, evaluated zero-shot, is competitive with domain-specific models.
- 2020
Denoising Diffusion Probabilistic Models
NeurIPS
A 2020 paper by Jonathan Ho, Ajay Jain and Pieter Abbeel that trained a U-Net to reverse a gradual noising process, making diffusion models a practical rival to GANs and paving the way for DALL-E 2, Imagen and Stable Diffusion.
- 2020
NeRF: Representing Scenes as Neural Radiance Fields for View Synthesis
arXiv
A 2020 paper by Mildenhall, Srinivasan, Tancik, Barron, Ramamoorthi and Ng that represents a scene as a neural radiance field: a network mapping 5D coordinates to density and colour, optimized from a sparse set of images with known camera poses.
- 2019
Mastering Atari, Go, chess and shogi by planning with a learned model
Nature
MuZero is a DeepMind reinforcement-learning algorithm that learns a model of its environment and plans inside that model, mastering Atari, Go, chess and shogi without being given the rules of those games.
- 2018
A Style-Based Generator Architecture for Generative Adversarial Networks
arXiv
This 2018 paper introduces a style-based GAN generator that separates high-level attributes from stochastic variation and allows scale-specific control, improving distribution quality, interpolation, and disentanglement.
- 2018
Large Scale GAN Training for High Fidelity Natural Image Synthesis
arXiv
A 2018 paper by Andrew Brock, Jeff Donahue and Karen Simonyan that trained generative adversarial networks at the largest scale attempted at the time, introduced BigGANs and set a new state of the art in class-conditional image synthesis.
- 2018
Glow: Generative Flow with Invertible 1x1 Convolutions
arXiv
A 2018 paper by Diederik P. Kingma and Prafulla Dhariwal presenting Glow, a flow-based generative model built on invertible 1x1 convolutions, which improved log-likelihood on standard benchmarks and could synthesise and manipulate large images.
- 2018
Neural Ordinary Differential Equations
arXiv
A 2018 paper by Chen, Rubanova, Bettencourt and Duvenaud that replaces a fixed sequence of hidden layers with a neural network describing the derivative of the hidden state, so outputs are computed by an ODE solver — yielding continuous-depth models with constant memory cost.[^1]
- 2018
Group Normalization
arXiv
Group Normalization is a 2018 paper by Yuxin Wu and Kaiming He that proposes normalizing channels in groups, independent of batch size, to address batch normalization's weakness when batches are small.
- 2017
A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play
Science
A 2017 arXiv paper, later published in Science, reporting that a single self-play reinforcement learning algorithm, AlphaZero, mastered chess, shogi and Go and beat strong specialised programs in each.