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Papers that changed AI, with a plain-language explainer for each.

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  1. 2025

    ARC-AGI-2: A New Challenge for Frontier AI Reasoning Systems

    arXiv

    A 2025 paper introducing ARC-AGI-2, a benchmark of input-output puzzle tasks built to measure abstract reasoning in frontier AI systems, with human testing as a baseline and a task set designed to give a more granular signal of progress.

    Research historyReasoningSimulation

  2. 2024

    FrontierMath: A Benchmark for Evaluating Advanced Mathematical Reasoning in AI

    arXiv

    FrontierMath is a benchmark of hundreds of original, unpublished mathematics problems written and vetted by expert mathematicians, introduced by Epoch AI to test advanced mathematical reasoning in AI. At release, state-of-the-art models solved under 2% of the problems.[^1][^2]

    Research historyReasoningScience

  3. 2024

    SAM 2: Segment Anything in Images and Videos

    arXiv

    SAM 2 is a Meta FAIR foundation model that segments objects in images and videos from simple prompts such as points, boxes or masks, released together with a large video segmentation dataset and training code.

    Research historyDeep learningMultimodal

  4. 2024

    Transformers are SSMs: Generalized Models and Efficient Algorithms Through Structured State Space Duality

    ICML

    Tri Dao and Albert Gu's paper introduces state space duality, a framework showing that structured state space models and attention variants are closely related, and uses it to derive Mamba-2, whose core layer runs 2 to 8 times faster than Mamba's.

    Research historyDeep learningTransformers & attention

  5. 2024

    Accurate structure prediction of biomolecular interactions with AlphaFold 3

    Nature

    AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.

    Deep learningScienceBiomedicine

  6. 2023

    Scaling deep learning for materials discovery

    Nature

    A 2023 Nature paper from researchers at Google DeepMind presenting a scaled-up deep-learning approach to predicting stable crystal structures, screening 2.2 million candidates and reporting a large jump in stability-prediction accuracy.

    Deep learningData & datasetsScience

  7. 2023

    GPQA: A Graduate-Level Google-Proof Q&A Benchmark

    arXiv

    GPQA is a benchmark of 448 expert-written multiple-choice questions in biology, physics and chemistry, built so that skilled non-experts cannot look the answers up, and hard enough that the strongest GPT-4 baseline scored 39% while domain experts reached 65%.

    Research historyReasoningScience

  8. 2023

    Segment Anything

    arXiv 2304.02643

    A 2023 paper that introduces the Segment Anything project: a promptable segmentation task, a model, and a dataset of over 1 billion masks on 11 million images, all released to advance foundation models for computer vision.

    Research historyData & datasetsComputer vision

  9. 2022

    Learning skillful medium-range global weather forecasting

    Science

    GraphCast is a graph neural network trained on four decades of reanalysis data that produces 10-day global weather forecasts at 0.25 degree resolution in under a minute, outperforming the leading operational deterministic systems on most verification targets.

    Deep learningScienceSimulation

  10. 2022

    Scalable Diffusion Models with Transformers (DiT)

    arXiv

    A 2022 paper by William Peebles and Saining Xie that replaces the U-Net backbone of diffusion models with a transformer operating on latent patches, showing that image quality improves predictably as compute grows and reaching a state-of-the-art FID of 2.27 on ImageNet 256×256.

    Research historyGenerative modelsImage generation

  11. 2022

    Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding (Imagen)

    arXiv

    Imagen is a text-to-image diffusion model that uses a large pretrained language model to encode prompts; it reached a zero-shot FID of 7.27 on COCO and introduced the DrawBench benchmark.

    Research historyMultimodalGenerative models

  12. 2022

    Magnetic control of tokamak plasmas through deep reinforcement learning

    Nature

    A 2022 Nature paper by Degrave, Felici and colleagues showing that a deep reinforcement learning controller can learn on its own to command all of a tokamak's magnetic control coils, producing and holding a range of plasma shapes.

    Deep learningHardware & computeScience

  13. 2021

    High-Resolution Image Synthesis with Latent Diffusion Models

    arXiv 2112.10752 (CVPR 2022)

    A 2021 paper by Rombach, Blattmann, Lorenz, Esser and Ommer that runs diffusion models inside the latent space of pretrained autoencoders, cutting the compute needed for high-resolution image synthesis while adding cross-attention for text and bounding-box control.

    Research historyGenerative modelsImage generation

  14. 2021

    Highly accurate protein structure prediction with AlphaFold

    Nature

    The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.

    Research historyScienceBiomedicine

  15. 2021

    Zero-Shot Text-to-Image Generation (DALL·E)

    arXiv

    A 2021 OpenAI paper describing a single 12-billion-parameter autoregressive transformer trained on 250 million image-text pairs, which generates images from text and, evaluated zero-shot, is competitive with domain-specific models.

    Research historyMultimodalGenerative models

  16. 2021

    Learning Transferable Visual Models From Natural Language Supervision (CLIP)

    ICML

    CLIP is an OpenAI model trained on 400 million image-text pairs to map pictures and sentences into one shared space, so it can classify images zero-shot from a written description.

    Foundation modelsMultimodalComputer vision

  17. 2020

    An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale (ViT)

    arXiv

    A 2020 paper showing that a plain Transformer applied directly to sequences of image patches, with no convolution at all, can match state-of-the-art convolutional networks on image classification.

    Research historyDeep learningComputer vision

  18. 2020

    An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale

    arXiv 2010.11929 (ICLR 2021)

    A 2020 paper by Alexey Dosovitskiy and colleagues showing that a pure Transformer applied directly to sequences of image patches — the Vision Transformer, or ViT — matches state-of-the-art convolutional networks on image classification when pre-trained on large amounts of data.

    Research historyComputer visionTransformers & attention

  19. 2020

    Denoising Diffusion Probabilistic Models

    NeurIPS

    A 2020 paper by Jonathan Ho, Ajay Jain and Pieter Abbeel that trained a U-Net to reverse a gradual noising process, making diffusion models a practical rival to GANs and paving the way for DALL-E 2, Imagen and Stable Diffusion.

    Deep learningGenerative modelsImage generation

  20. 2020

    NeRF: Representing Scenes as Neural Radiance Fields for View Synthesis

    arXiv

    A 2020 paper by Mildenhall, Srinivasan, Tancik, Barron, Ramamoorthi and Ng that represents a scene as a neural radiance field: a network mapping 5D coordinates to density and colour, optimized from a sparse set of images with known camera poses.

    Research historyGenerative modelsComputer vision