Models

A speech-to-text model from Microsoft AI released in April 2026 that transcribes 25 languages, runs Copilot's Voice Mode, and starts at $0.36 per hour of audio.

EnterpriseMultimodalCloud

Baichuan-M3 is a new-generation open-source medical-enhanced language model with 235 billion parameters, built on Qwen3-235B-A22B and released under Apache 2.0 in January 2026.

Large language modelsOpen sourceChina

Amazon Nova 2 is the second generation of Amazon's Nova models, released at AWS re:Invent in December 2025. Its first member, Nova 2 Lite, is a fast reasoning model available in Amazon Bedrock with a 1-million-token context.

Large language modelsAgents & tool useMultimodal

Qwen3-Max is Alibaba's proprietary trillion-parameter language model, released in September 2025 and served through Alibaba's API. It is the Max-tier flagship that followed Qwen2.5-Max.

Large language modelsChinaFoundation models

Baichuan-M2 is an open-source medical-enhanced model with 32 billion parameters, built on Qwen2.5-32B and released under Apache 2.0 for research and reference.

Large language modelsOpen sourceChina

Amazon Nova Premier is the most capable model of the first Nova generation, available in Amazon Bedrock from 30 April 2025. It handles text, images and video with a 1-million-token context window, and also serves as a teacher model for smaller Nova models.

Large language modelsEnterpriseMultimodal

A speech-to-speech foundation model in Amazon's Nova family, announced on 8 April 2025, which handles recognition, understanding and speech generation in a single model rather than a chain of separate ones.

Agents & tool useMultimodalGenerative models

Hunyuan-T1 is Tencent's deep-reasoning model, officially released on 21 March 2025 and built on the Hunyuan-TurboS base. Tencent did not release its weights.

Large language modelsChinaReasoning

Hunyuan Turbo S is a fast-thinking model released by Tencent on 27 February 2025, built on a hybrid Mamba-Transformer design with 560 billion total parameters. Its weights were not released.

Large language modelsChinaFoundation models

Qwen2.5-Max is Alibaba's large mixture-of-experts model, announced in January 2025. It was offered through Qwen Chat and the Alibaba Cloud API, and its weights were not released.

Large language modelsChinaFoundation models

Baichuan-M1 is Baichuan's medical model line, released on 24 January 2025 with Baichuan-M1-preview and the open Baichuan-M1-14B, which Baichuan described as trained from scratch for medicine.

Large language modelsOpen sourceChina

Amazon Nova is Amazon's family of foundation models, introduced on 3 December 2024 and offered exclusively in Amazon Bedrock. It spans text understanding models from Micro to Pro, plus Canvas for images and Reel for video, and was succeeded by Nova 2 in December 2025.

Large language modelsEnterpriseMultimodal

Hunyuan Turbo is Tencent's large language model, released on Tencent Cloud in September 2024 and tuned for lower training and serving costs. It was succeeded in February 2025 by Hunyuan Turbo S, which cut API prices further.

Large language modelsChinaEnterprise

ESM3 is a protein generative model announced by EvolutionaryScale in June 2024 that reasons over sequence, structure and function together, and generated a fluorescent protein estimated to sit over 500 million years of evolution away from known ones.

Open sourceFoundation modelsGenerative models

Cohere's 104-billion-parameter language model, announced in April 2024, is tuned for retrieval-augmented generation and multi-step tool use in business settings; it launched first on Microsoft Azure and was also released as open weights.

Large language modelsEnterpriseAgents & tool use

Mistral Large is the French company Mistral AI's first flagship proprietary large language model, released on 26 February 2024 with a 32K-token context window, native fluency in five languages, and built-in function calling and JSON output.

Large language modelsEnterpriseCloud

Baichuan 3 is a closed language model with more than one hundred billion parameters, released by Baichuan on 29 January 2024. The company reported that it matched or beat GPT-4 on several Chinese benchmarks and on Chinese medical tasks.

Large language modelsChinaFoundation models

Hunyuan is Tencent's first proprietary large foundation model, unveiled in September 2023 and offered to enterprises through Tencent Cloud. The line was later branded Hy.

Large language modelsChinaEnterprise

Amazon Titan is a family of foundation models built by Amazon for Amazon Bedrock, covering text generation, embeddings and image generation. It was announced in 2023 and later succeeded by Amazon Nova.

Large language modelsEnterpriseCloud

A pair of medical question-answering language models described in arXiv papers of 26 December 2022 and 16 May 2023; the first introduced the MultiMedQA benchmark, and Med-PaLM 2 reached up to 86.5% on MedQA.

Large language modelsSafety & governanceScience

RoseTTAFold is a three-track neural network for protein structure prediction, published by the Baker lab in 2021; its accuracy approached AlphaFold2's at CASP14, it models protein–protein complexes from sequence alone, and it is distributed as open code with a public web server.

Research historyOpen sourceDeep learning

AlphaFold2 is DeepMind's protein structure prediction system, announced in 2020. It reached accuracy competitive with experimental methods in many cases, and work in this area received half of the 2024 Nobel Prize in Chemistry.

Research historyDeep learningScience

DeepMind's first protein-structure prediction system, which placed first overall in the 2018 CASP13 blind assessment by estimating probability distributions of distances between residues.

Research historyDeep learningScience