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Papers that changed AI, with a plain-language explainer for each.
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- 2024
FlashAttention-3: Fast and Accurate Attention with Asynchrony and Low-precision
arXiv
FlashAttention-3 is an attention algorithm for NVIDIA Hopper (H100) GPUs that reaches up to 75% utilization in FP16 and close to 1.2 PFLOPs/s in FP8, using asynchronous execution and low-precision techniques.
- 2024
Accurate structure prediction of biomolecular interactions with AlphaFold 3
Nature
AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.
- 2023
FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioning
arXiv
FlashAttention-2 is a 2023 revision of the FlashAttention attention kernel that reorganizes work across GPU thread blocks and warps, roughly doubling speed and reaching up to 73% of the A100's theoretical peak throughput.
- 2023
QLoRA: Efficient Finetuning of Quantized LLMs
arXiv
QLoRA is a finetuning method that trains a 65B-parameter language model on a single 48GB GPU while matching full 16-bit finetuning quality, using 4-bit quantization, double quantization and paged optimizers.
- 2022
FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness
arXiv
FlashAttention is an exact attention algorithm built around GPU memory traffic: by tiling computation so intermediates stay on chip, it cuts reads and writes to high bandwidth memory, training Transformers faster and enabling longer sequences.
- 2021
Highly accurate protein structure prediction with AlphaFold
Nature
The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.
- 2021
LoRA: Low-Rank Adaptation of Large Language Models
arXiv
LoRA is a fine-tuning method that freezes a pre-trained model's weights and trains small low-rank matrices injected into each layer, cutting trainable parameters and memory by orders of magnitude.
- 2020
GShard: Scaling Giant Models with Conditional Computation and Automatic Sharding
arXiv
GShard, submitted to arXiv in June 2020, is a set of annotation APIs and an XLA compiler extension from Google that lets existing model code express parallel computation, scaling a sparsely gated mixture-of-experts translation model past 600 billion parameters.
- 2015
U-Net: Convolutional Networks for Biomedical Image Segmentation
arXiv
A convolutional network for biomedical image segmentation, posted to arXiv on May 18, 2015, that trains end to end from very few annotated images and won the ISBI cell tracking challenge 2015 in its categories.
- 2011
Torch7: A Matlab-like Environment for Machine Learning
A 2011 workshop paper by Ronan Collobert, Koray Kavukcuoglu and Clement Farabet describing Torch7, a Lua-based numeric computing framework and machine learning library built for flexible experimentation on fast low-level kernels.
- 2010
Understanding the difficulty of training deep feedforward neural networks
AISTATS / PMLR
A 2010 paper by Xavier Glorot and Yoshua Bengio on why deep feedforward networks are hard to train: sigmoid saturation under random initialization and layer Jacobians whose singular values sit far from 1, plus a new initialization scheme that converges substantially faster.
- 2004
MapReduce: Simplified Data Processing on Large Clusters
OSDI
Jeffrey Dean and Sanjay Ghemawat's 2004 OSDI paper presents MapReduce, a programming model in which users write a map function and a reduce function while the run-time system parallelizes the work across large clusters of commodity machines.