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Papers that changed AI, with a plain-language explainer for each.
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- 2025
ARC-AGI-2: A New Challenge for Frontier AI Reasoning Systems
arXiv
A 2025 paper introducing ARC-AGI-2, a benchmark of input-output puzzle tasks built to measure abstract reasoning in frontier AI systems, with human testing as a baseline and a task set designed to give a more granular signal of progress.
- 2024
Accurate structure prediction of biomolecular interactions with AlphaFold 3
Nature
AlphaFold 3, published in Nature in May 2024, extends structure prediction to biomolecular interactions, reporting greater accuracy than docking tools for protein–ligand binding and than AlphaFold-Multimer v.2.3 for antibody–antigen complexes.
- 2022
Learning skillful medium-range global weather forecasting
Science
GraphCast is a graph neural network trained on four decades of reanalysis data that produces 10-day global weather forecasts at 0.25 degree resolution in under a minute, outperforming the leading operational deterministic systems on most verification targets.
- 2022
Magnetic control of tokamak plasmas through deep reinforcement learning
Nature
A 2022 Nature paper by Degrave, Felici and colleagues showing that a deep reinforcement learning controller can learn on its own to command all of a tokamak's magnetic control coils, producing and holding a range of plasma shapes.
- 2021
Highly accurate protein structure prediction with AlphaFold
Nature
The Nature paper described AlphaFold's methods, system design, and evaluation for protein-structure prediction.
- 2020
NeRF: Representing Scenes as Neural Radiance Fields for View Synthesis
arXiv
A 2020 paper by Mildenhall, Srinivasan, Tancik, Barron, Ramamoorthi and Ng that represents a scene as a neural radiance field: a network mapping 5D coordinates to density and colour, optimized from a sparse set of images with known camera poses.
- 2019
Mastering Atari, Go, chess and shogi by planning with a learned model
Nature
MuZero is a DeepMind reinforcement-learning algorithm that learns a model of its environment and plans inside that model, mastering Atari, Go, chess and shogi without being given the rules of those games.
- 2019
On the Measure of Intelligence (ARC-AGI)
arXiv
A 2019 paper by Francois Chollet that defines intelligence as skill-acquisition efficiency and introduces the Abstraction and Reasoning Corpus (ARC), a benchmark of grid tasks that assumes no specialised knowledge or language.
- 2017
A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play
Science
A 2017 arXiv paper, later published in Science, reporting that a single self-play reinforcement learning algorithm, AlphaZero, mastered chess, shogi and Go and beat strong specialised programs in each.
- 2015
U-Net: Convolutional Networks for Biomedical Image Segmentation
arXiv
A convolutional network for biomedical image segmentation, posted to arXiv on May 18, 2015, that trains end to end from very few annotated images and won the ISBI cell tracking challenge 2015 in its categories.
- 1990
Elephants Don't Play Chess
Rodney Brooks's 1990 paper argued for building artificial intelligence from the ground up, with ongoing physical interaction with the environment as the main constraint on design, rather than through the abstract manipulation of symbols that had dominated the field for roughly thirty years.